.:~~:.
Assalamualaikum wrt wbt. :)

Semoga kita semua berada di bawah rahmat dan lembayung kasihnya. Terima kasih Allah atas kemurahanMu yang tidak berkira memberi nikmat meskipun hati ini sering rapuh, lupa bersyukur.

Entah kenapa hati saya jadi sayu benar mendengar bait-bait lagu Maha Melihat nyanyian Opick. Palpitation akibat minum cappucino tatkala malam menjengah diganti dengan rasa sebak. Kurang benar saya bersyukur sejak akhir-akhir ini. Selalu mengeluh. Selalu mencari apa yang tiada. Allahu...

Minggu ini bermulalah minggu Student Selected Component aka research. Saya memilih untuk menjalankan kerja di laboratory tentang proteomic study of aromatase inhibitor resistant in cancer cells. Macam menarik kan? Sebab tu saya pilih meskipun terpaksa menjadi anak buah tunggal supervisor saya. Namun sudah dua hari kunjungan saya ke lab dihampakan dengan ketiadaan supervisor. Rupa-rupanya beliau sedang out station. Lalu saya ada satu minggu cuti. In a way, bagus tapi cuak juga takut tidak sempat menyiapkan project tepat pada masanya. InsyaAllah sempat (sambil menepuk2 bahu memberikan semangat).

Moh le kita membaca serba sedikit tentang aromatase inhibitor ye cik lin.

Aromatase inhibitors stop the production of estrogen in post-menopausal women. Aromatase inhibitors work by blocking the enzyme aromatase, which turns the hormone androgen into small amounts of estrogen in the body. This means that less estrogen is available to stimulate the growth of hormone-receptor-positive breast cancer cells.

Aromatase inhibitors can't stop the ovaries from making estrogen, so aromatase inhibitors only work in post-menopausal women.

There are three aromatase inhibitors:

  • Arimidex (chemical name: anastrozole)
  • Aromasin (chemical name: exemestane)
  • Femara (chemical name: letrozole)

Each is a pill, usually taken once a day. Arimidex is the only aromatase inhibitor available in generic form.

Benefit :

Based on the results, most doctors recommend that after initial treatment (surgery and possibly chemotherapy and radiation therapy):

  • an aromatase inhibitor is the best hormonal therapy to start with. When treating early-stage, hormone-receptor-positive breast cancer, aromatase inhibitors have more benefits and fewer serious side effects than tamoxifen.
  • switching to an aromatase inhibitor after taking tamoxifen for 2 to 3 years (for a total of 5 years of hormonal therapy) offers more benefits than 5 years of tamoxifen.
  • taking an aromatase inhibitor for 5 years after taking tamoxifen for 5 years continues to reduce the risk of the cancer coming back, compared to no treatment after tamoxifen.
Side effect :

-heart problem

-osteoporosis

-broken bones (jadi, kena buat bone density test to check ok!)

-joint stiffness/pain

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